Author

P. Guhathakurta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

D. D. Thomas· 3 shared A. L. Carter· 2 shared A. Wilson· 2 shared B. A. Colson· 2 shared T. A. Bunch· 2 shared V. C. Lepak· 2 shared A. E. Atang· 1 shared A. R. Keller· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiophysics

D. D. Thomas

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4 papers

Recent·Most cited

BiophysicsbioRxivApr 3, 2023

Drug discovery for heart failure targeting myosin-binding protein C

T. A. Bunch, P. Guhathakurta, A. Thompson…·B. A. Colson

This study identifies small molecules that modulate cMyBP-C interactions with actin or myosin, aiming to develop therapies for heart failure.

DOI 10.1016/j.jbc.2023.105369

proteomicsexperimental assay

𝕏 PostBluesky

BiophysicsbioRxivPreprintNov 8, 2022

Identification of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia

P. Guhathakurta, R. T. Rebbeck, S. A. Denha…·A. W. Avery

The paper develops an in vitro FRET assay to identify small molecule modulators of the L253P mutant β-III-spectrin actin-binding domain, identifying potential drug candidates for SCA5 treatment.

DOI 10.1101/2022.11.08.515660

humanproteomics

𝕏 PostBluesky

BiophysicsbioRxivPreprintMar 24, 2021

High-throughput screen using fluorescence lifetime detects compounds that modulate myosin-binding protein C interactions with actin

T. A. Bunch, P. Guhathakurta, V. C. Lepak…·B. A. Colson

This study identifies small-molecule inhibitors of actin-cMyBP-C binding using a fluorescence lifetime assay and validates their mechanism with complementary techniques.

DOI 10.1101/2021.03.24.436879

fluorescence / live-cell microscopyexperimental assay

𝕏 PostBluesky

BiophysicsbioRxivMay 19, 2020

Actin-binding compounds, discovered by FRET-based high-throughput screening, differentially affect skeletal and cardiac muscle

P. Guhathakurta, L. A. Phung, E. Prochniewicz…·D. D. Thomas

This study evaluates actin-binding compounds identified through TR-FRET screening, showing differential effects on skeletal and cardiac muscle actin and myofibril function.

DOI 10.1016/j.bpj.2019.11.3213

humanproteomics

𝕏 PostBluesky