Cancer BiologybioRxivPreprint
Leukotrienes promote stem cell self-renewal and chemoresistance in acute myeloid leukemia
C. Y. Park, A. W. Stranahan, I. Berezniuk…·M. Khalaj
This study identifies ALOX5 as a mediator of chemoresistance in AML by promoting LSC self-renewal through LTB4-BLTR signaling, suggesting ALOX5 inhibition could enhance chemotherapy efficacy.
DOI 10.1101/2022.02.07.479440