Cancer BiologybioRxivPreprint
β-catenin programs a tissue-specific epigenetic vulnerability in aggressive adrenocortical carcinoma
D. R. Mohan, K. S. Borges, I. Finco…·G. D. Hammer
This study shows that β-catenin maintains adrenocortical carcinoma differentiation through chromatin and histone interactions, and that targeting EZH2 can disrupt this process and inhibit tumor growth.
DOI 10.1101/2022.07.02.497654