β-catenin programs a tissue-specific epigenetic vulnerability in aggressive adrenocortical carcinoma
D. R. Mohan, K. S. Borges, I. Finco, C. R. LaPensee, J. Rege, A. L. Solon, D. W. Little, T. Else, M. Q. Almeida, D. Dang, J. Haggerty-Skeans, A. A. Apfelbaum, M. Vinco, A. Wakamatsu, B. M. P. Mariani, , G. D. Hammer
This study shows that β-catenin maintains adrenocortical carcinoma differentiation through chromatin and histone interactions, and that targeting EZH2 can disrupt this process and inhibit tumor growth.
bioRxiv · Jul 2, 2022 · PreprintCancer Biology