Influence of the microenvironment on the modulation of the host response by the typhoid toxin
O. C. Martin, D. Butter, E. Paparouna, S. D. Theodorou, M. M. Haykal, E. Boutet-Robinet, T. Tebaldi, A. Bergonzini, M. Lopez Chiloeches, A. Wakeham, M. Rhen, T. Mak, V. Gorgoulis, I. S. Pateras, T. Frisan
This study investigates how typhoid toxin modulates host immune responses in health and disease by inducing DNA damage and senescence, with effects dependent on the host's inflammatory state.
bioRxiv · Jun 4, 2020Immunology