Author

A. Wellner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Organism:yeast· 1

Frequent Co-Authors

C. C. Liu· 2 shared D. S. Marks· 2 shared J.-E. Shin· 2 shared A. C. Kruse· 1 shared A. G. Schmidt· 1 shared A. Kruse· 1 shared A. Y. Shaw· 1 shared B. M. Hauser· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPharmacology & Toxicology

C. C. Liu

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2 papers

Recent·Most cited

An in silico method to assess antibody fragment polyreactivity

E. P. Harvey, J.-E. Shin, M. A. Skiba, G. R. Nemeth, J. D. Hurley, A. Wellner, A. Y. Shaw, V. G. Miranda, J. K. Min, C. C. Liu, D. S. Marks, A. Kruse

The paper develops a machine learning model to assess and reduce polyreactivity in nanobody sequences, achieving high accuracy and practical application through a web server.

bioRxiv · Jan 12, 2022 · PreprintPharmacology & Toxicology

Rapid generation of potent antibodies by autonomous hypermutation in yeast

A. Wellner, C. McMahon, M. S. A. Gilman, J. R. Clements, S. Clark, K. M. Nguyen, M. H. Ho, J.-E. Shin, J. Feldman, B. M. Hauser, T. M. Caradonna, L. M. Wingler, A. G. Schmidt, D. S. Marks, J. Abraham, , C. C. Liu

This paper introduces AHEAD, a yeast-based system for rapid antibody generation through autonomous hypermutation, achieving high-affinity antibodies against SARS-CoV-2 and other targets in just 2 weeks.

bioRxiv · Nov 11, 2020Bioengineering