Author

J. Abraham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2

Frequent Co-Authors

J. Pan· 3 shared A. Coscia· 2 shared L. E. Clark· 2 shared P. Yang· 2 shared S. A. Clark· 2 shared A. Bruna· 1 shared A. C. Kruse· 1 shared A. G. Martin· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersMicrobiology

J. Pan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural and functional analysis of the Nipah virus polymerase complex

S. Hu, H. Kim, P. Yang, Z. Yu, B. Ludeke, S. Mobilia, J. Pan, M. Stratton, Y. Bian, R. Fearns, J. Abraham

This study determines the cryo-EM structure of the Nipah virus polymerase complex and identifies key domains critical for replication and transcription.

bioRxiv · May 29, 2024Microbiology

Structural basis for VLDLR recognition by eastern equine encephalitis virus

P. Yang, W. Li, X. Fan, J. Pan, C. J. Mann, H. Varnum, L. E. Clark, S. A. Clark, A. Coscia, K. N. Smith, V. Brusic, J. Abraham

This study determines the structures of EEEV and SFV spike glycoproteins bound to VLDLR, revealing distinct binding modes that explain how different alphaviruses use the same receptor.

bioRxiv · Nov 14, 2023Microbiology

Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of lysine demethylation and oxidative phosphorylation

S. S. Dhar, C. Brown, A. Rizvi, L. Reed, S. Kotla, C. Zod, J. Abraham, J.-I. Abe, V. Rajaram, K. Chen, M. Lee

This study shows that heterozygous Kmt2d loss promotes medulloblastoma by enhancing tumor-promoting programs and that combining LSD1 inhibition with oxidative phosphorylation blockade reduces tumorigenicity.

bioRxiv · Oct 29, 2023 · PreprintCancer Biology

Modelling drug responses and evolutionary dynamics using triple negative breast cancer patient-derived xenografts

A. Shea, Y. Eyal-Lubling, D. Guerrero-Romero, R. Manzano Garcia, W. Greenwood, M. O'Reilly, D. Georgopoulou, M. Callari, G. Lerda, S. Wix, A. Giovannetti, R. Masina, E. Esmaeilishirazifard, A. G. Martin, A. Nagano, , A. Bruna

This paper uses TNBC patient-derived xenografts to model drug responses and evolutionary dynamics, revealing a novel mechanism of olaparib response and synergistic effects with salinomycin.

bioRxiv · Jan 10, 2023 · PreprintCancer Biology

Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2

S. A. Clark, L. E. Clark, J. Pan, A. Coscia, L. G. A. McKay, S. Shankar, R. I. Johnson, A. Griffiths, J. Abraham

The paper identifies germline-biased neutralizing antibodies against SARS-CoV-2 and shows that affinity gains do not always correlate with neutralization potency.

bioRxiv · Nov 13, 2020Microbiology

Rapid generation of potent antibodies by autonomous hypermutation in yeast

A. Wellner, C. McMahon, M. S. A. Gilman, J. R. Clements, S. Clark, K. M. Nguyen, M. H. Ho, J.-E. Shin, J. Feldman, B. M. Hauser, T. M. Caradonna, L. M. Wingler, A. G. Schmidt, D. S. Marks, J. Abraham, , C. C. Liu

This paper introduces AHEAD, a yeast-based system for rapid antibody generation through autonomous hypermutation, achieving high-affinity antibodies against SARS-CoV-2 and other targets in just 2 weeks.

bioRxiv · Nov 11, 2020Bioengineering