Author

C. McMahon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Ecology· 2 Biochemistry· 1 Bioengineering· 1 Cancer Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:behavioral assay· 1

Frequent Co-Authors

A. C. Kruse· 4 shared I. Jonsen· 2 shared L. M. Wingler· 2 shared M. S. A. Gilman· 2 shared Y. Wang· 2 shared A. Amcheslavsky· 1 shared A. Anderson· 1 shared A. E. Gillen· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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4 shared papersPharmacology & Toxicology

A. C. Kruse

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A novel type of monocytic leukemia stem cell revealed by the clinical use of venetoclax-based therapy

S. Pei, A. E. Gillen, I. T. Shelton, B. M. Stevens, M. Gasparetto, K. Engel, S. Staggs, Y. Wang, W. Showers, A. Inguva, M. L. Amaya, M. Minhajuddin, A. Winters, S. B. Patel, H. Tolison, , C. T. Jordan

The paper identifies a new type of monocytic leukemia stem cell (m-LSC) in AML patients treated with venetoclax, showing its distinct characteristics and clinical relevance.

Cancer Discovery · Sep 6, 2023Peer-reviewedCancer Biology

Substrate-Specific Function of PNPLA3 Facilitates Hepatic VLDL-Triglyceride Secretion During Stimulated Lipogenesis

S. M. Johnson, H. Bao, C. McMahon, Y. Chen, S. Burr, A. Anderson, K. Madeyski-Bengtson, D. Linden, X. Han, J. Liu

This study defines the physiological role of wild-type PNPLA3 in maintaining hepatic VLDL-TG secretion and shows that the I148M variant impairs this function during lipogenic conditions.

bioRxiv · Aug 30, 2023 · PreprintPhysiology

Antibodies Expand the Scope of Angiotensin Receptor Pharmacology

M. A. Skiba, S. M. Sterling, S. Rawson, M. S. A. Gilman, H. Xu, G. R. Nemeth, J. D. Hurley, P. Shen, D. P. Staus, J. Kim, C. McMahon, M. K. Lehtinen, L. M. Wingler, A. C. Kruse

This study develops nanobody antagonists against the AT1R receptor, showing they can selectively bind and modulate the receptor with tunable ligand selectivity.

bioRxiv · Aug 23, 2023Pharmacology & Toxicology

Dispersal of southern elephant seals (Mirounga leonina) from Davis Base, Antarctica: Combining population genetics and tracking data

M. Chua, S. Ho, C. McMahon, I. Jonsen, M. de Bruyn

This study combines genetic and tracking data to analyze the dispersal and genetic diversity of southern elephant seals at Davis Base, Antarctica, identifying their natal origins and foraging behaviors.

bioRxiv · Nov 26, 2021 · PreprintEcology

Rapid generation of potent antibodies by autonomous hypermutation in yeast

A. Wellner, C. McMahon, M. S. A. Gilman, J. R. Clements, S. Clark, K. M. Nguyen, M. H. Ho, J.-E. Shin, J. Feldman, B. M. Hauser, T. M. Caradonna, L. M. Wingler, A. G. Schmidt, D. S. Marks, J. Abraham, , C. C. Liu

This paper introduces AHEAD, a yeast-based system for rapid antibody generation through autonomous hypermutation, achieving high-affinity antibodies against SARS-CoV-2 and other targets in just 2 weeks.

bioRxiv · Nov 11, 2020Bioengineering

Oral administration of a single anti-CfaE nanobody provides broadly cross-protective immunity against major pathogenic Enterotoxigenic Escherichia coli strains

A. Amcheslavsky, A. Wallace, M. Ejemel, Q. Li, C. McMahon, M. Stoppato, S. Giuntini, Z. A. Schiller, J. Pondish, J. R. Toomey, R. Schneider, J. Meisinger, R. Heukers, A. C. Kruse, E. M. Barry, , Y. Wang

This study shows that oral administration of a single nanobody provides broad protection against multiple ETEC strains by targeting conserved epitopes.

bioRxiv · Jun 16, 2020 · PreprintMicrobiology

Movement responses to environment: fast inference of variation among southern elephant seals with a mixed effects model

I. Jonsen, C. McMahon, T. Patterson, M. Auger-Methe, R. Harcourt, M. Hindell, S. Bestley

The paper uses a mixed effects model to rapidly infer individual variation in southern elephant seal movement responses to environmental factors.

Ecology · Dec 24, 2018Peer-reviewedEcology

Platform for rapid nanobody discovery in vitro

C. McMahon, A. S. Baier, S. Zheng, R. Pascolutti, J. X. Ong, S. C. Erlandson, D. Hilger, A. M. Ring, A. Manglik, A. C. Kruse

This paper presents an in vitro platform for rapid nanobody discovery using yeast surface display, demonstrating its application to various antigens including lipid flippase and G protein-coupled receptors.

bioRxiv · Jun 16, 2017Biochemistry