Chemotherapy synergizes with cancer vaccines and expands stem-like TCF1+CD8+ T cells
L. Noblecourt, A. Wicki, V. Pereira-Almeida, J. McAuliffe, E. Steffke, S. Panetti, R. A. Ramirez-Valdez, V. Chandrasekar, A. Jainarayanan, A. V. Hill, B. J. Van den Eynde, C. S. K. Leung
This study shows that chemotherapy, specifically CarboTaxol, synergizes with cancer vaccines and anti-PD-1 to improve tumor control and survival by expanding stem-like TCF1+CD8+ T cells.
bioRxiv · Dec 18, 2023 · PreprintImmunology