Author

A. Jainarayanan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

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Research Focus:cell type annotation· 4 Research Focus:cell-cell communication· 3 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

M. L. Dustin· 2 shared A. Bernand· 1 shared A. Filer· 1 shared A. Frampton· 1 shared A. Jonsson· 1 shared A. Magen· 1 shared A. V. Hill· 1 shared A. V. Ratushny· 1 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCell Biology

M. L. Dustin

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Author profile →

4 papers

Recent·Most cited

Perforin-mediated pore formation at the lytic synapse triggers the canonical pyroptotic cell death pathway

B. McKenzie, M.-P. Puissegur, L. Demeersseman, F. Rodriguez, E. Cini, A. Jainarayanan, M. A. Widdess, C. C. Staton, L. Chen, V. Sibaud, L. Lamant, M. L. Dustin, A. Bernand, S. Mueller, S. Valitutti

This study shows perforin triggers pyroptosis in target cells by activating the NLRP3/caspase-1/gasdermin D pathway, while sustained CTL interaction leads to apoptosis.

bioRxiv · May 24, 2024 · PreprintCell Biology

Chemotherapy synergizes with cancer vaccines and expands stem-like TCF1+CD8+ T cells

L. Noblecourt, A. Wicki, V. Pereira-Almeida, J. McAuliffe, E. Steffke, S. Panetti, R. A. Ramirez-Valdez, V. Chandrasekar, A. Jainarayanan, A. V. Hill, B. J. Van den Eynde, C. S. K. Leung

This study shows that chemotherapy, specifically CarboTaxol, synergizes with cancer vaccines and anti-PD-1 to improve tumor control and survival by expanding stem-like TCF1+CD8+ T cells.

bioRxiv · Dec 18, 2023 · PreprintImmunology

Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments

S. Sivakumar, A. Jainarayanan, E. Arbe-Barnes, M. N. Leathlobhair, P. K. Sharma, S. Amin, L. Heij, S. Hegde, A. Magen, F. Tucci, B. Sun, S. Wu, N. M. Anand, H. Slawinski, S. Revale, , R. J. M. Bashford-Rogers

The paper analyzes single-cell immune multi-omics data from PDAC to identify differential immunosuppressive mechanisms in distinct tumour microenvironments.

bioRxiv · Aug 31, 2023 · PreprintImmunology

A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

T. Thomas, C. Rich-Griffin, M. Pohin, M. Friedrich, D. Aschenbrenner, J. Pakpoor, A. Jainarayanan, A.-I. Voda, R. Sanches Peres, E. Nee, D. Sathananthan, D. Kotliar, J. Turner, S. Nayar, F. Zhang, , C. Buckley

This study creates a therapeutic atlas of anti-TNF treatment in IBD, showing disease- and therapy-specific cellular changes and identifying IFN signalling as a potential target for JAK inhibition.

bioRxiv · May 5, 2023Immunology