A murine model with JAK2V617F expression in both hematopoietic cells and vascular endothelial cells recapitulates the key features of human myeloproliferative neoplasm
H. Zhang, A. Yeware, S. Lee, H. Zhan
This study creates a murine model with JAK2V617F in both hematopoietic and vascular cells, showing it mimics human MPN features like disease progression and cardiovascular issues.
bioRxiv · Aug 24, 2021Cancer Biology