Mitotic Regulators and the SHP2-MAPK Pathway Promote Insulin Receptor Endocytosis and Feedback Regulation of Insulin Signaling
E. Choi, S. Kikuchi, H. Gao, K. Brodzik, I. Nassour, A. Yopp, A. G. Singal, H. Zhu, H. Yu
This study shows that mitotic regulators and the SHP2-MAPK pathway promote insulin receptor endocytosis and feedback regulation of insulin signaling, improving insulin sensitivity when feedback is blocked.
bioRxiv · Sep 17, 2018Cell Biology