E. Choi

A HigB-like toxin promotes non-replicating Salmonella inside macrophages by inhibiting ribonuclease III

This study identifies a HigB-like toxin in Salmonella that inhibits RNase III, leading to non-replicating bacteria within macrophages.

B lymphocytes acquire myeloid and autoimmune phenotypes via the downregulation of lymphocyte-specific protein-1

This study shows that LSP1 deficiency in B cells leads to myeloid-like traits and autoantibody production, accelerating lupus in mice and correlating with reduced LSP1 in lupus patients.

Destabilized host-parasite dynamics in newly founded populations

The paper experimentally studies host-parasite dynamics in newly founded stickleback populations, finding destabilized infection rates and rapid eco-evolutionary responses.

A strict requirement in proteasome substrates for spacing between ubiquitin tag and degradation initiation elements

The paper shows that the distance between ubiquitin tags and degradation initiation elements determines proteasome-mediated protein degradation efficiency.

Differential substrate affinity and catabolite repression enable preferential use of urea by ammonia-oxidizing bacteria

The paper shows that ammonia-oxidizing microorganisms use different regulatory strategies for ammonia and urea, enabling coexistence by minimizing competition.

Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor

This study reports cryo-EM structures of modified IGF1R and IR complexes, showing that disulfide-linked CTs are critical for receptor activation and signaling.

BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved antitumor activity

This paper evaluates BOXR1030, a CAR T cell therapy co-expressing GPC3-targeted CAR and GOT2, showing enhanced T cell metabolism and improved antitumor activity in preclinical models.

Helicobacter pylori accelerates KRAS-dependent gastric dysplasia

This study shows that Helicobacter pylori infection accelerates KRAS-driven gastric dysplasia in mice by promoting inflammation, altering gene expression, and increasing proliferation of preneoplastic glands.

Engineered developmental niche enables predictive phenotypic screening in human dystrophic cardiomyopathy

This study develops an engineered cardiac niche to mature hPSC-derived cardiomyocytes, revealing arrhythmia in dystrophin mutants and identifying drug effects.

NanoMEA: a versatile platform for high-throughput analysis of structure-function relationships in human stem cell-derived excitable cells and tissues

This paper introduces nanoMEAs to enhance the structural and functional properties of hPSC-derived cardiomyocytes and neurons, improving their response to pharmacological agents.

Mitotic Regulators and the SHP2-MAPK Pathway Promote Insulin Receptor Endocytosis and Feedback Regulation of Insulin Signaling

This study shows that mitotic regulators and the SHP2-MAPK pathway promote insulin receptor endocytosis and feedback regulation of insulin signaling, improving insulin sensitivity when feedback is blocked.

Multiple reference genome sequences of hot pepper reveal the massive evolution of plant disease resistance genes by retroduplication

The paper reports multiple pepper genomes and finds that retroduplication via LTR-retrotransposons drives expansion of disease resistance genes in plants.