Novel synthetic ecteinascidins exhibit potent anti-melanoma activity by suppressing super-enhancer-driven oncogenic transcription
M. Cigrang, j. Obid, i. Davidson, M. Nogaret, t. ye, g. davidson, P. Catez, P. Berico, c. capelli, C. Marechal, A. Zachayus, C. Elly, T.-K. Li, E. Compe, P. Aviles, , F. Coin
This study shows novel synthetic ecteinascidins effectively treat melanoma by inhibiting super-enhancer-driven oncogenic transcription, even in resistant models.
bioRxiv · Mar 26, 2024 · PreprintCancer Biology