A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process
G. Noske, A. Nakamura, V. Gawriljuk, R. Fernandes, G. Lima, H. Rosa, H. Pereira, A. Zeri, A. Nascimento, M. Freire, G. Oliva, A. S. de Godoy
This paper presents a crystal structure of an immature SARS-CoV-2 main protease, revealing conformational changes that hinder dimerization and activity, and identifies potential therapeutic targets.
bioRxiv · Dec 23, 2020Biochemistry