Author

M. Freire

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 4 Biophysics· 2 Evolutionary Biology· 2 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 8 Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Assay:proteomics· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:differential expression· 4 Approach:statistical model· 3 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

S. Choudhury· 3 shared C. Pardo-Diaz· 2 shared C. Salazar· 2 shared H. Alqaderi· 2 shared H. Jang· 2 shared K. Altabtbaei· 2 shared M. Alghounaim· 2 shared M. Linares· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

S. Choudhury

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Sputum production and salivary microbiome in COVID-19 patients reveals oral-lung axis

K. Y.-F. Lu, H. Alqaderi, S. Bin Hasan, H. Alhazmi, M. Alghounaim, S. Devarajan, M. Freire, K. Altabtbaei

This study examines the oral microbiome and cytokine profiles in COVID-19 patients with and without sputum production, finding significant microbial and cytokine differences associated with sputum production.

bioRxiv · Feb 29, 2024Microbiology

Multimodal illumination platform for 3D single-molecule super-resolution imaging throughout mammalian cells

T. Nelson, S. Vargas-Hernandez, M. Freire, S. Cheng, A.-K. Gustavsson

This paper introduces a multimodal illumination platform for 3D single-molecule super-resolution imaging in mammalian cells, improving signal-to-background ratio and localization precision.

bioRxiv · Feb 8, 2024Biophysics

Host-Microbiome Associations in Saliva Predict COVID-19 Severity

H. Alqaderi, K. Altabtbaei, J. L. Espinoza, S. Bin-Hasan, M. Alghounaim, A. Alawady, A. Altabtabae, S. AlJamaan, S. Devarajan, T. AlShammari, M. B. Eid, M. Matsuoka, H. Jang, C. Dupont, M. Freire

The paper examines the relationship between salivary microbiome and host parameters in COVID-19 patients, finding that microbiome diversity and salivary cytokines predict disease severity.

bioRxiv · May 2, 2023Immunology

Minimal cell JCVI-syn3B as a chassis to reveal the mechanisms behind Mycoplasma host-pathogen interactions

D. M. d. C. Bittencourt, D. M. Brown, N. Assad-Garcia, M. R. Lynott, L. Sun, L. A. M. P. d. Melo, M. Freire, J. I. Glass

The paper investigates host-mycoplasma interactions using minimized Mycoplasma mycoides strains, identifying genes essential for attachment but not parasitism.

bioRxiv · Sep 19, 2022 · PreprintMicrobiology

Does sexual conflict contribute to the evolution of novel warning patterns?

A. Hausmann, M. Freire, S. A. Alfthan, C.-Y. M. Kuo, M. Linares, O. McMillan, C. Pardo-Diaz, C. Salazar, R. M. Merrill

This study investigates whether sexual conflict contributes to the diversification of warning patterns in Heliconius butterflies, finding that sexual conflict can assist pattern diversification but genetic architecture and sex-specific costs also play roles.

bioRxiv · May 16, 2022Evolutionary Biology

Persistent Immune and Clotting Dysfunction Detected in Saliva and Blood Plasma after COVID-19

H. Jang, S. Choudhury, Y. Yu, B. L. Sievers, T. Gelbart, H. Singh, S. A. Rawlings, A. Proal, G. S. Tan, D. Smith, M. Freire

The paper identifies persistent immune and clotting dysfunction in saliva and plasma of COVID-19 patients 4-6 weeks post-symptom resolution, highlighting saliva as a viable alternative to plasma for monitoring immune and inflammatory sequelae.

bioRxiv · Mar 18, 2022Immunology

A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process

G. Noske, A. Nakamura, V. Gawriljuk, R. Fernandes, G. Lima, H. Rosa, H. Pereira, A. Zeri, A. Nascimento, M. Freire, G. Oliva, A. S. de Godoy

This paper presents a crystal structure of an immature SARS-CoV-2 main protease, revealing conformational changes that hinder dimerization and activity, and identifies potential therapeutic targets.

bioRxiv · Dec 23, 2020Biochemistry

Light environment influences mating behaviours during the early stages of divergence in tropical butterflies

A. E. Hausmann, C.-Y. Kuo, M. Freire, N. Rueda-M, M. Linares, C. Pardo-Diaz, C. Salazar, R. M. Merrill

This study shows that light conditions affect mating behaviors in Heliconius butterflies, with differences in visual attraction contributing to low-level assortative mating.

bioRxiv · Jul 28, 2020Evolutionary Biology

Netome: The Molecular Characterization of Neutrophil Extracellular Traps (NETs)

D. Scieszka, Y.-H. Lin, W. Li, S. Choudhury, Y. Yu, M. Freire

This study characterizes the molecular composition of neutrophil extracellular traps (NETs) using omics approaches, revealing specific genomic and proteomic signatures.

bioRxiv · May 18, 2020 · PreprintImmunology

Host-Microbial Interactions in Systemic Lupus Erythematosus and Periodontitis

L. Pessoa, G. Aleti, S. Choudhury, D. Nguyen, T. Yaskell, Y. Zhang, L. Weizhong, K. Nelson, L. Santos Neto, A. Sant Ana, M. Freire

This study investigates the relationship between periodontal microbiota and systemic inflammation in SLE patients, finding that periodontal pathogens correlate with increased proinflammatory cytokines.

Frontiers in Immunology · Nov 12, 2019Peer-reviewedImmunology

The GRASP domain in Golgi Reassembly and Stacking Proteins: differences and similarities between lower and higher Eukaryotes

L. F. Mendes, N. A. Fontana, C. G. Oliveira, M. Freire, J. Lopes, F. Melo, A. J. Costa-Filho

This study compares GRASP proteins from humans and lower eukaryotes to understand differences in Golgi cisternae assembly and evolution.

bioRxiv · Jan 16, 2019Biophysics