In vivo inactivation of RAD51-mediated homologous recombination leads to premature aging, but not to tumorigenesis
G. Matos-Rodrigues, V. Barroca, A.-A. Muhammad, A. Allouch, S. Koundrioukoff, D. Lewandowski, E. Despras, J. Guirouilh-Barbat, L. Frappart, P. Kannouche, P. Dupaigne, E. Le Cam, J.-L. Perfettini, P.-H. Romeo, M. Debatisse, , B. S. Lopez
This study shows that inactivating RAD51 in mice causes premature aging but not cancer, suggesting RAD51 is critical for progenitor cell homeostasis.
bioRxiv · Jan 17, 2022 · PreprintCancer Biology