Molecular BiologybioRxivPreprint
A human papillomavirus 16 E2-TopBP1 dependent SIRT1-p300 acetylation switch regulates mitotic viral and human protein levels
Apurva Tadimari Prabhakar, Claire D. James, Aya H. Youssef…·Iain M. Morgan
This paper identifies a mitotic E2-TopBP1 complex that inactivates SIRT1, promoting E2 acetylation and stability through p300, which protects against ubiquitination and proteasomal degradation.
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