Author

Aaron Sykes

University of PennsylvaniaPrimary ORCID profile (0009-0004-8436-9872 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Aaron SykesiD1 paper · University of Pennsylvania

Biology Disciplines

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Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

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CAROL J. DEUTSCHiD· 1 shared Lannawill CaruthiD· 1 shared Shefali S. VermaiD· 1 shared Sophia Gross· 1 shared Toshinori HoshiiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperPhysiology

CAROL J. DEUTSCHORCID

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1 paper

Recent·Most cited

PhysiologyJournal of Molecular BiologyPeer-reviewedMay 21, 2025

Disease-associated Kv1.3 variants are energy compromised with impaired nascent chain folding.

Aaron Sykes, Lannawill Caruth, Sophia Gross…·CAROL J. DEUTSCH

This study investigates how disease-associated Kv1.3 variants affect protein folding and stability, finding that R114G variant shows reduced folding probability and structural instability.

DOI 10.1016/j.jmb.2025.169226

humanproteomics

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