ImmunologybioRxivPreprint
TREM2+ macrophages accumulate in alveoli of human pulmonary tuberculosis providing a permissive niche for bacterial growth
Rosane M. B. Teles, Chaouki Benabdessalem, Jonathan Perrie…·Robert L. Modlin
This study identifies TREM2+ lipid-laden macrophages in alveolar TB pneumonia that support Mtb survival, contrasting with granulomas, and shows pharmacological reversal of this immunometabolic state.
DOI 10.1101/2025.07.15.664002