Adrie J. C. Steyn

This study uses 3D reconstruction and optimal transport modeling to analyze TLS development in TB-infected lungs, revealing distinct maturation trajectories and spatial dynamics.

This paper introduces a human-in-the-loop framework using AI foundation models and sparse autoencoders to interpret H&E histology images and integrate them with molecular spatial profiling.

This study identifies an aromatic patch in Mtb Wbl proteins that mediates interaction with the primary sigma 70 factor, revealing a conserved binding mechanism and evolutionary relationship with actinobacterial phages.

This study identifies MenG inhibitors that restore bedaquiline susceptibility in resistant tuberculosis strains through menaquinone pathway disruption.

This study uses a mouse model of TB infection to investigate fibrosis mechanisms, finding persistent inflammatory macrophages and elevated matrix remodeling enzymes during treatment.

This study shows that targeting ALOX5/LTA4H signaling reduces TB-induced lung damage and improves bactericidal activity through macrophage-driven inflammation.

This study quantifies antibiotic resistance in tuberculosis using genomic data and MIC measurements to identify genetic determinants of resistance and hypersensitivity across multiple drugs.

This paper uses RNA in situ hybridization to detect Mycobacterium tuberculosis mRNA in human tissue, identifying Mtb in ZN-negative samples and revealing two distinct Mtb populations.