Pharmacology & ToxicologyJournal of Medicinal ChemistryPeer-reviewed
A Lipid Prodrug Strategy Enhances Targeted Protein Degrader CNS Pharmacokinetics
Georges A. Leconte, Gillian E. Gadbois, Yadira J Sepulveda…·Fleur M. Ferguson
This study identifies fatty acid promoieties that improve CNS exposure of targeted protein degraders by enhancing pharmacokinetics and BBB permeability.
DOI 10.1021/acs.jmedchem.5c00866