Author

Aiden J. Aceves

California Institute of Technology

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Bioengineering· 1

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Approach:statistical model· 1

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Jingzhou WangiD· 1 shared Nicholas J FriesenhahniD· 1 shared Stephen L. MayoiD· 1 shared

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Jingzhou WangORCID

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BioengineeringProtein Engineering Design and SelectionPeer-reviewedJan 1, 2025

CDRxAbs: Antibody Small-Molecule Conjugates with Computationally Designed Target-Binding Synergy

Jingzhou Wang, Aiden J. Aceves, Nicholas J Friesenhahn, Stephen L. Mayo

This paper introduces CDRxAbs, a new class of antibody-small-molecule conjugates designed to enhance target binding affinity and specificity through computational protein design.

DOI 10.1093/protein/gzaf004

protein structuredeep learning

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