Cancer BiologyCell ReportsPeer-reviewed
Hi-C profiling in tissues reveals 3D chromatin-regulated breast tumor heterogeneity and tumor-specific looping-mediated biological pathways
Lavanya Choppavarapu, Kun Fang, Tianxiang Liu…·Victor X. Jin
The paper uses Hi-C profiling in breast tissues to reveal 3D chromatin-regulated tumor heterogeneity and identifies CA2 as a driver of tamoxifen resistance through enhancer-promoter looping.