Lavanya Choppavarapu

This study shows that inhibiting EZH2 alters 3D chromatin structure in SCLC, reactivating MHC genes and enhancing immunogenicity.

Nuc3DMap integrates MNase-seq, Hi-C, and Micro-C data to delineate finer nucleosome-based 3D chromatin architecture and identifies distinct subtypes of chromatin features.

The paper uses Hi-C profiling in breast tissues to reveal 3D chromatin-regulated tumor heterogeneity and identifies CA2 as a driver of tamoxifen resistance through enhancer-promoter looping.

The paper integrates scHi-C and scRNA-seq data to identify 3D-regulated cell subpopulations in breast cancer, revealing new chromatin structures and biological contexts.

This study shows that inhibiting β-catenin/CBP interaction with ICG-001 alters 3D chromatin structure in pancreatic cancer, affecting insulin signaling and promoting tumor growth.