Cancer BiologybioRxiv
De novo lipogenesis pathway is a vulnerability in IDH1 mutant glioma
Lubayna S. Elahi, Michael C. Condro, Riki Kawaguchi…·Harley I. Kornblum
This study identifies de novo lipogenesis as a vulnerability in IDH1 mutant gliomas, showing that HDAC inhibition and FASN targeting reduce tumor growth and improve survival.
DOI 10.1038/s44324-024-00021-6