Molecular BiologybioRxivPreprint
Interplay Between KRAS and LZTR1 Protein Turnover, Controlled by CUL3/LZTR1 E3 Ubiquitin Ligase, is Disrupted by KRAS Mutations
Andreas Damianou, Zhu Liang, Frederik Heymann Lassen…·Benedikt Mathias Kessler
The paper shows KRAS mutations disrupt its interaction with LZTR1, affecting protein stability via the CUL3 ubiquitin ligase complex, contributing to oncogenesis.
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