Zhu Liang

This study shows IL-22 promotes mucus-secreting cells in the small intestine, protecting mice from cholera by reducing V. cholerae colonization.

This paper introduces a high-throughput activity proteomics pipeline for discovering deubiquitinase inhibitors, identifying potent and selective inhibitors with minimal optimization.

This study compares T-cell-driven IL-1β production in humans and mice, finding distinct molecular mechanisms involving different signaling pathways and enzymes.

The paper identifies UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia through proximity proteomics and functional assays.

The paper shows KRAS mutations disrupt its interaction with LZTR1, affecting protein stability via the CUL3 ubiquitin ligase complex, contributing to oncogenesis.