This study identifies critical negatively charged residues in SARS-CoV-1 and SARS-CoV-2 fusion peptides that are essential for Ca2+ binding and membrane ordering activity.

DOI 10.1101/2021.11.03.467161

humanprotein structure

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Molecular BiologyJournal of Molecular BiologyPeer-reviewedMar 18, 2021

SARS-CoV-2 Fusion Peptide has a Greater Membrane Perturbating Effect than SARS-CoV with Highly Specific Dependence on Ca2+

Alex Liqi Lai, Jack H. Freed

This study compares the membrane perturbation effects of SARS-CoV-2 and SARS-CoV fusion peptides, showing SARS-2 has greater membrane ordering and Ca2+ dependence.

73 citationstop 4%

humanstatistical model

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