Cancer BiologybioRxivPreprint
p53Y220C-BET-bifunctionals (tPRIMEs) drive p53Y220C-mutant cancer cells into apoptosis
Charlotte Kelley, Jae Young Ahn, Scott F. Rusin…·Alexandra B. Lantermann
This study develops p53Y220C-tPRIMEs, bifunctional molecules that induce ternary complexes with p53Y220C and BET proteins, leading to apoptosis and growth inhibition in p53 mutant cancer cells.
3 citations