NeuroscienceScientific ReportsPeer-reviewed
Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924
Sarah Lépine, Gilles Maussion, Alexandria Schneider…·Thomas M. Durcan
The paper identifies MLN4924 as a compound that improves cell viability in TDP-43 mutant motor neurons by targeting NEDD8-activating enzyme.
5 citations