NeuroscienceMolecular TherapyPeer-reviewed
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration
René L. Vidal, Denisse Sepúlveda, Paulina Troncoso-Escudero…·Claudio A. Hetz
This study shows that forcing dimerization between ATF6f and XBP1s enhances UPR activity, reducing protein aggregation in neurodegenerative disease models.