Cell BiologybioRxiv
Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain
Eva M García-Cuesta, Pablo Martínez, Karthik Selvaraju…·Mario Mellado
This paper identifies a small molecule that modulates CXCR4 nanoclustering without affecting ligand binding, improving therapeutic potential over existing CXCR4 antagonists.
DOI 10.7554/elife.93968