Cell BiologybioRxivPreprint
The CUL4-DDB1-DCAF1 E3 ubiquitin ligase complex regulates PLK4 protein levels to prevent premature centriole duplication
Josina Grossmann, Anne-Sophie Kratz, Alina Kordonsky…·Ingrid Hoffmann
The paper shows that the CUL4-DDB1-DCAF1 E3 ligase complex targets PLK4 for degradation in G2 phase to prevent premature centriole duplication.
DOI 10.1101/2023.09.13.555514