Author

Alison M. Karst

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Molecular Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

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Kai DobersteiniD· 1 shared Paul KroegeriD· 1 shared Ronny DrapkiniD· 1 shared

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2018-2018 · peak 1/yr

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Kai DobersteinORCID

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1 paper

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Molecular BiologybioRxivPreprintMay 18, 2018

Replication stress induced by CCNE1 overexpression creates a dependency on XRCC2 at the replication fork

Kai Doberstein, Alison M. Karst, Paul Kroeger, Ronny Drapkin

The paper identifies a dependency on XRCC2 in CCNE1-overexpressing tumors, showing XRCC2's role in stabilizing replication forks and its synthetic lethality with CCNE1.

DOI 10.1101/325563

humanbulk RNA-seq

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