NeurosciencebioRxivPreprint
C9orf72 polyGA knock-in mice exhibit mild motor and proteomic changes consistent with ALS/FTD
Carmelo Milioto, Mireia Carcolé, Matteo Zanovello…·Adrian M. Isaacs
This study creates (GA)400 knock-in mice to model C9orf72 polyGA expression, finding mild motor dysfunction and proteomic changes in the spinal cord.
DOI 10.1101/2025.05.30.656994