NeurosciencebioRxivPreprint
PACAP-PAC1 Receptor Inhibition is Effective in Models of Opioid-Induced Medication Overuse Headache
Zachariah Bertels, Elizaveta Mangutov, Kendra Siegersma…·Amynah A. A. Pradhan
This study shows that inhibiting PACAP-PAC1 receptors reduces opioid-induced chronic headache in mouse models by blocking PACAPergic mechanisms.
DOI 10.1101/2021.12.05.471295