MicrobiologybioRxivPreprint
TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2
Anupriya Aggarwal, Christina Fichter, Vanessa Milogiannakis…·Stuart Grant Turville
The paper shows Omicron SARS-CoV-2 lineages rely on ACE2 without TMPRSS2 complexes for entry, due to changes in the ACE2 Collectrin-Like Domain affecting TMPRSS2 activation.
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