Author

Andy Burnim

National Institutes of Health

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Evolutionary Biology· 1

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Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

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Alexander Edward LipkaiD· 1 shared Holger SondermanniD· 1 shared Keith Dufault‐ThompsoniD· 1 shared Sofia MortenseniD· 1 shared Xiaofang JiangiD· 1 shared

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1 shared paperEvolutionary Biology

Alexander Edward LipkaORCID

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Evolutionary BiologyScience AdvancesPeer-reviewedAug 12, 2026

Ancestral proteins trace the emergence of substrate specificity and oligomerization within bacterial DEDDy dinucleases

Sofia Mortensen, Andy Burnim, Keith Dufault‐Thompson…·Holger Sondermann

This study reconstructs ancestral bacterial DEDDy dinucleases to trace the evolution of substrate specificity and oligomerization from a dimeric ancestor with intermediate preferences.

DOI 10.1126/sciadv.aef1581

bacteria (other)protein structure

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