BiochemistryNucleic Acids ResearchPeer-reviewed
CRISPR-Cas12a exhibits metal-dependent specificity switching
Giang T. Nguyen, Michael A. Schelling, Akshara Raju…·Dipali G. Sashital
This study shows that Cas12a's specificity changes with Mg2+ concentration, affecting cleavage efficiency and phage escape routes in different cellular environments.
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