Author

Anna Mechel

Universitätsmedizin Göttingen

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Neuroscience· 1

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Approach:experimental assay· 1

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Björn TwellsieckiD· 1 shared C. Alexander BoeckeriD· 1 shared Erika L.F. HolzbauriD· 1 shared Jessica M. Grein· 1 shared Lennart Evers· 1 shared Maria‐Sol Cima‐OmoriiD· 1 shared Markus ZweckstetteriD· 1 shared Michel Fricke· 1 shared

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Björn TwellsieckORCID

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1 paper

Recent·Most cited

NeuroscienceCell ReportsPeer-reviewedMay 21, 2026

Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation

Michel Fricke, Anna Mechel, Lennart Evers…·C. Alexander Boecker

This study shows that PPM1H knockout disrupts axonal autophagy and increases alpha-synuclein aggregation in neurons, linking LRRK2 hyperactivity to Parkinson disease pathology.

1 citation

experimental assay

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