ImmunologybioRxivPreprint
EROS is required for phagocyte NADPH oxidase function in humans and its deficiency causes Chronic Granulomatous Disease.
David C. Thomas, Louis-Marie Charbonnier, Andrea Schejtman…·Kenneth G.C. Smith
This paper identifies EROS as a novel cause of chronic granulomatous disease by showing that EROS deficiency in humans leads to loss of gp91phox-p22phox heterodimer and impaired phagocyte function.