PhysiologybioRxivPreprint
Bidirectional Control of Coronary Vascular Resistance by Eicosanoids via a Novel GPCR
Nabil J. Alkayed, Zhiping Cao, Zu Yuan Qian…·Sanjiv Kaul
The paper identifies GPR39 as a microvascular smooth muscle cell receptor regulated by opposing eicosanoids, 15-HETE and 14,15-EET, which modulate coronary vascular resistance through distinct mechanisms.
DOI 10.1101/420406