NeuroscienceNature CommunicationsPeer-reviewed
Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding
Ella W. Mathews, Sydney R. Coffey, Annette Gärtner…·Jeffrey B. Carroll
This study investigates how different HTT-lowering therapies affect somatic instability in HD mice, finding that transcriptional repression and CAG repeat binding reduce SI without lowering HTT levels.
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