Author

Anton Delwig

Genentech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

Alicia A. Nugent· 1 shared Amber L. Cramer· 1 shared Anjani Ganti· 1 shared Brett M. BabiniD· 1 shared Bryan Chan· 1 shared Bryan D. MoyeriD· 1 shared Casper C. HoogenraadiD· 1 shared Chang Hoon ChoiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Alicia A. Nugent

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2 papers

Recent·Most cited

SARM1 orthosteric base exchange inhibitors cause subinhibitory SARM1 activation

Rebecca Leahey, Martin Weber, Chang Hoon Cho, Seong Kwon Hur, Amber L. Cramer, Karla Manzanares, Brett M. Babin, Gladys de Leon Boenig, Taylor Kring, Liling Liu, Yusi Cui, Anjani Ganti, John P. Evans, Marika Nespi, Justin Ly, , Flora I. Hinz

The paper shows that subinhibitory concentrations of orthosteric SARM1 inhibitors can activate SARM1, leading to NAD consumption, neurodegeneration, and biomarker release in neurons.

bioRxiv · Aug 6, 2024 · PreprintNeuroscience

Discovery of a Selective, State-Independent Inhibitor of NaV1.7 by Modification of Guanidinium Toxins

Hassan Pajouhesh, Jacob T. Beckley, Anton Delwig, Holly S. Hajare, George Luu, Dennis Monteleone, Xiang Zhou, Joseph Ligutti, Shanti M. Amagasu, Bryan D. Moyer, David C. Yeomans, J. Du Bois, John V. Mulcahy

This paper describes the discovery of ST-2262, a selective NaV1.7 inhibitor with state-independent action, showing reduced pain sensitivity in non-human primates.

Scientific Reports · Sep 9, 2020Peer-reviewedNeuroscience