NeurosciencebioRxivPreprint
SARM1 orthosteric base exchange inhibitors cause subinhibitory SARM1 activation
Rebecca Leahey, Martin Weber, Chang Hoon Cho…·Flora I. Hinz
The paper shows that subinhibitory concentrations of orthosteric SARM1 inhibitors can activate SARM1, leading to NAD consumption, neurodegeneration, and biomarker release in neurons.