Cell BiologyFrontiers in BiophysicsPeer-reviewed
IDRs lead the way: Cooperativity between intrinsically disordered regions and structured interaction domains drives enrichment in transcription condensates
Arad Abazari, Dinitha Yasas Caldera, Alisha Budhathoki…·Jan-Hendrik Spille
The paper shows that intrinsically disordered regions (IDRs) alone are insufficient to explain the enrichment of full-length transcription proteins in condensates, suggesting a need for structured domains in binding interactions.
DOI 10.3389/frbis.2026.1891221