GeneticsbioRxivPreprint
Longevity-associated SMAD3 non-coding centenarian variant impairs a cell-type specific enhancer to reduce inflammation
Jiping Yang, Archana Tare, Lei Justan Zhang…·Yousin Suh
The paper identifies a longevity-associated SMAD3 non-coding variant that impairs a cell-type specific enhancer, reducing inflammation and senescence in endothelial cells and improving healthspan in a mouse model.
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