NeurosciencebioRxivPreprint
Synapse-related protein alterations and estradiol deficiency associate with early Parkinsonism in female A53T-α-synuclein transgenic mice fed on a high-fat diet
Swati Aggarwal, Ankit Biswas, Naman Kharbanda…·Tushar Kanti Maiti
This study shows that a high-fat diet accelerates Parkinson's-like symptoms in female mice, linked to synapse damage and low estradiol, while males show immune pathway changes.
DOI 10.1101/2025.10.22.678296