Molecular BiologybioRxivPreprint
Mitochondrial topoisomerase I (Top1MT) prevents the onset of metabolic dysfunction-associated steatohepatitis (MASH) in mice
S. Baechler, LK Saha, VM Factor…·Yves G. Pommier
This study shows that Top1MT deficiency in mice leads to severe MASH with liver steatosis, inflammation, and fibrosis after a high-fat diet.
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